American Joint Replacement Research-Collaborative (AJRR-C)

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Data-driven joint replacement research

The AJRR-C leverages big data resources, such as registries and databases, for total joint replacement research. Image provided by the American Association of Orthopedic Surgeons' American Joint Replacement Registry, which serves as the collaborative's Resource Core.

The AJRR-C facilitates innovative interdisciplinary clinical research to improve care and outcomes for patients receiving total joint replacements (arthroplasty).

Its research involves linking existing and new data about patients receiving joint replacements from multiple data sources at Mayo Clinic and from national data drawn from the American Joint Replacement Registry (AJRR), which is part of a family of national orthopedic surgery subspecialty registries maintained by the American Academy of Orthopedic Surgeons (AASO). A major goal of this collaboration is to build additional multicenter collaborations nationally to support a burgeoning community of researchers involved in registry science.

As the AJRR-C shares its expertise, educational and data analytics resources across Mayo Clinic and with the research community at large, its multidisciplinary research team leverages big data resources for total joint replacement research. It aspires to provide customized methodology resources in epidemiology, biostatistics, health sciences research and medical informatics nationally in support of musculoskeletal registry research.

The American Joint Replacement Research-Collaborative seeks to advance clinical research in the field by providing high-quality consulting services and resources. It seeks to facilitate optimal use of existing databases and research networks, train the next generation of orthopedic clinical investigators, and build productive scientific collaborations.

Addressing unmet clinical needs

Total joint replacement is the most common and fastest growing surgery in the United States. An estimated 1.4 million procedures are performed annually, and almost 8 million Americans have artificial joints. As baby boomers age and the demand for improved quality of life grows, the number of total joint replacement procedures is expected to increase further.

To ensure that the high surgical demand is met with the best patient care, investigators around the world need unique research resources. These include access to large, high-quality and rich data sources and registries, state-of-the-art clinical research standards, and information technologies to overcome methodological and practical challenges in their research.

The American Joint Replacement Research-Collaborative provides the expertise and data access needed for innovative, methodologically rigorous and interdisciplinary clinical research in total joint replacement. It addresses clinical research needs through:

Facilitated access to high-quality, rich data sources and national registry data
Customized consultations with researchers at Mayo Clinic and other institutions
Informatics and methodology support
Pilot project grants to support early- and mid-career researchers

Affiliations

The collaborative is affiliated with several Mayo Clinic research and clinical groups, including:

Department of Orthopedic Surgery
Department of Health Sciences Research
Division of Epidemiology
Division of Adult Reconstructive Surgery
Division of Biomedical Statistics and Informatics
Division of Orthopedic Surgery Research
Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery
Mayo Clinic Total Joint Registry
Rochester Epidemiology Project

The collaborative was established with support from the American Academy of Orthopedic Surgeons (AAOS) family of registries, beginning with their flagship, the American Joint Replacement Registry (AJRR), and from researchers at organizations nationwide, including:

Matthew P. Abdel, M.D., Mayo Clinic
Kevin J. Bozic, M.D., M.B.A., University of Texas at Austin
James A. Browne, M.D., University of Virginia
William H. Crown, Ph.D., Optum Labs
Craig J. Della Valle, M.D., Rush University
George J. Haidukewych, M.D., Orlando Orthopaedic Center
Brian R. Hallstrom, M.D., University of Michigan
James Huddleston, M.D., Stanford University
Joshua J. Jacobs, M.D., Rush University
William A. Jiranek, M.D., Duke University
Gwo-Chin Lee, M.D., University of Pennsylvania
Jay R. Lieberman, M.D., University of Southern California
William J. Maloney, M.D., Stanford University
R. Michael Meneghini, M.D., Indiana University
Dennis Nam, M.D., M.Sc., Rush University
Ryan Nunley, M.D., Washington University in St. Louis
Douglas R. Osmon, M.D., Mayo Clinic
Scott M. Sporer, M.D., Rush University
Bryan D. Springer, M.D., OrthoCarolina

Collaborative team

The AJRR-C is led by a multidisciplinary team with expertise in orthopedic surgery, epidemiology, and bioinformatics and statistics.

Daniel J. Berry, M.D.
Director, American Joint Replacement Research-Collaborative (AJRR-C)
Director, Administrative Core
David G. Lewallen, M.D.
Associate Director, American Joint Replacement Research-Collaborative (AJRR-C)
Associate Director, Administrative Core
Hilal Maradit Kremers, M.D.
Director, Methodology Core
Katrina L. Devick, Ph.D.
Co-Director, Methodology Core
Dirk R. Larson, M.S.
Operations Director, Methodology Core
Elizabeth B. Habermann, Ph.D.
Methodology Core — Health Services Research
Sunghwan Sohn, Ph.D.
Methodology Core — Informatics
Kristina Rosinia
American Academy of Orthopedic Surgeons' American Joint Replacement Registry
Director, Resource Core
Christina R. Stenzel
Program Coordinator, American Joint Replacement Research-Collaborative (AJRR-C)

External advisory committee

The AJRR-C's external advisory committee provides strategic guidance, administrative oversight and support.

James Huddleston, M.D.
Mohit Bhandari, M.D.
Michael Bolognesi, M.D.
James Browne, M.D.
John Callaghan, M.D.
Stephan Dunning, Ph.D.
Brian Hallstrom, M.D.
Jeffrey Katz, M.D.
Daniel Riddle, Ph.D.
Kurt Spindler, M.D.
Bryan Springer, M.D.