As the AJRR-C shares its expertise, educational and data analytics resources across Mayo Clinic and with the research community at large, its multidisciplinary research team leverages big data resources for total joint replacement research. It aspires to provide customized methodology resources in epidemiology, biostatistics, health sciences research and medical informatics nationally in support of musculoskeletal registry research.
The American Joint Replacement Research-Collaborative seeks to advance clinical research in the field by providing high-quality consulting services and resources. It seeks to facilitate optimal use of existing databases and research networks, train the next generation of orthopedic clinical investigators, and build productive scientific collaborations.
Addressing unmet clinical needs
Total joint replacement is the most common and fastest growing surgery in the United States. An estimated 1.4 million procedures are performed annually, and almost 8 million Americans have artificial joints. As baby boomers age and the demand for improved quality of life grows, the number of total joint replacement procedures is expected to increase further.
To ensure that the high surgical demand is met with the best patient care, investigators around the world need unique research resources. These include access to large, high-quality and rich data sources and registries, state-of-the-art clinical research standards, and information technologies to overcome methodological and practical challenges in their research.
The American Joint Replacement Research-Collaborative provides the expertise and data access needed for innovative, methodologically rigorous and interdisciplinary clinical research in total joint replacement. It addresses clinical research needs through:
- Facilitated access to high-quality, rich data sources and national registry data
- Customized consultations with researchers at Mayo Clinic and other institutions
- Informatics and methodology support
- Pilot project grants to support early- and mid-career researchers
The collaborative is affiliated with several Mayo Clinic research and clinical groups, including:
The collaborative was established with support from the American Academy of Orthopedic Surgeons (AAOS) family of registries, beginning with their flagship, the American Joint Replacement Registry (AJRR), and from researchers at organizations nationwide, including:
- Matthew P. Abdel, M.D., Mayo Clinic
- Kevin J. Bozic, M.D., M.B.A., University of Texas at Austin
- James A. Browne, M.D., University of Virginia
- William H. Crown, Ph.D., Optum Labs
- Craig J. Della Valle, M.D., Rush University
- George J. Haidukewych, M.D., Orlando Orthopaedic Center
- Brian R. Hallstrom, M.D., University of Michigan
- James Huddleston, M.D., Stanford University
- Joshua J. Jacobs, M.D., Rush University
- William A. Jiranek, M.D., Duke University
- Gwo-Chin Lee, M.D., University of Pennsylvania
- Jay R. Lieberman, M.D., University of Southern California
- William J. Maloney, M.D., Stanford University
- R. Michael Meneghini, M.D., Indiana University
- Dennis Nam, M.D., M.Sc., Rush University
- Ryan Nunley, M.D., Washington University in St. Louis
- Douglas R. Osmon, M.D., Mayo Clinic
- Scott M. Sporer, M.D., Rush University
- Bryan D. Springer, M.D., OrthoCarolina
The AJRR-C is led by a multidisciplinary team with expertise in orthopedic surgery, epidemiology, and bioinformatics and statistics.
- Daniel J. Berry, M.D.
Director, American Joint Replacement Research-Collaborative (AJRR-C)
Director, Administrative Core
- David G. Lewallen, M.D.
Associate Director, American Joint Replacement Research-Collaborative (AJRR-C)
Associate Director, Administrative Core
- Hilal Maradit Kremers, M.D.
Director, Methodology Core
- Katrina L. Devick, Ph.D.
Co-Director, Methodology Core
- Dirk R. Larson, M.S.
Operations Director, Methodology Core
- Elizabeth B. Habermann, Ph.D.
Methodology Core — Health Services Research
- Nilay D. Shah, Ph.D.
Methodology Core — Health Services Research
- Sunghwan Sohn, Ph.D.
Methodology Core — Informatics
- Kristina Rosinia
American Academy of Orthopedic Surgeons' American Joint Replacement Registry
Director, Resource Core
- Christina R. Stenzel
Program Coordinator, American Joint Replacement Research-Collaborative (AJRR-C)
External advisory committee
The AJRR-C's external advisory committee provides strategic guidance, administrative oversight and support.
- James Huddleston, M.D.
- Mohit Bhandari, M.D.
- Michael Bolognesi, M.D.
- James Browne, M.D.
- John Callaghan, M.D.
- Stephan Dunning, Ph.D.
- Brian Hallstrom, M.D.
- Jeffrey Katz, M.D.
- Daniel Riddle, Ph.D.
- Kurt Spindler, M.D.
- Bryan Springer, M.D.